ABSTRACT
Due to COVID-19 barriers, the needs of international container ports have become more important than in the past. Therefore, it is very critical and essential for the scientific developments of port-logistics. To gain the scientific developments of port logistics, effective and efficient evaluation methods for decision-making are indispensable, especially for assessing service performance of international container ports based on dependent evaluation criteria (DEC). Among numerous decision-making methods, technique for order preference by similarity to ideal solution (TOPSIS) was often expanded under fuzzy environments into fuzzy multi-criteria decision-making (FMCDM) to preserve imprecise messages. The FMCDM was able to be associated with quality function deployment (QFD) into a hybrid method to solve problems with DEC. To gain more messages, QFD and TOPSIS are combined and then expanded under interval-valued fuzzy environment (IVFE) to solve a FMCDM problem with DEC. Practically, evaluating service performance of international container ports in Taiwan and the surrounding sea areas is considered a problem with DEC because the related evaluation criteria are partially connected. By the hybrid method of combining QFD with TOPSIS under IVFE, international container ports with DEC are effectively and efficiently evaluated for service performance, and more insights are gained than the past for establishing essential fundamentals in recent scientific developments of port logistics on account of breaking down COVID-19 barriers.
ABSTRACT
Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven inflammation is the leading cause of acute cardiac injury associated with coronavirus disease 2019 (COVID-19). However, in-depth knowledge of the injury characteristics of the heart affected by inflammation is lacking. In this study, using a quantitative spatial proteomics strategy that combines comparative anatomy, laser-capture microdissection, and histological examination, we establish a region-resolved proteome map of the myocardia and microvessels with obvious inflammatory cells from hearts of patients with COVID-19. A series of molecular dysfunctions of myocardia and microvessels is observed in different cardiac regions. The myocardia and microvessels of the left atrial are the most susceptible to virus infection and inflammatory storm, suggesting more attention should be paid to the lesion and treatment of these two parts. These results can guide in improving clinical treatments for cardiovascular diseases associated with COVID-19.